Biomechanics of vascular mechanosensation and remodeling

Biomechanics of vascular mechanosensation and remodeling

Flowing blood exerts a frictional force, fluid shear stress (FSS), on the endothelial cells that line the blood and lymphatic vessels. The magnitude, pulsatility, and directional characteristics of FSS are constantly sensed by the endothelium. Sustained increases or decreases in FSS induce vessel remodeling to maintain proper perfusion of tissue. In this review, we discuss these mechanisms and ...

Metalloproteinases, Mechanical Factors and Vascular Remodeling

Chronic increases in arterial blood flow elicit an adaptive response of the arterial wall, leading to vessel enlargement and reduction in wall shear stress to physiological baseline value. Release of nitric oxide from endothelial cells exposed to excessive shear is a fundamental step in the remodeling process, and potentially triggers a cascade of events, including growth factor induction and m...

Inflammation and Vascular Remodeling

1Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan 2Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Shitsukawa, Ehime Tōon 791-0295, Japan 3Department of Cardiology, Nagoya University Graduate School of Medi...

Biomechanics in vascular biology and cardiovascular disease.

Introduction Biodegradable stents have the potential to avoid long-term complications of conventional stents such as in-stent restenosis and late stent thrombosis, and could allow for a restoration of vasomotion and vessel growth which makes them suitable for e.g. paediatric applications [1]. To investigate the mechanics of this new type of stent via finite element simulations, we developed a n...

Cardiac Myocytes and Mechanosensation